114 UV-produced D 3 inhibits basal cell carcinoma (BCC) carcinogenesis in Ptch1 +/- mice
نویسندگان
چکیده
منابع مشابه
Basal cell carcinoma (BCC)
A. Environmental factors 1. Non-Ionizing Radiation – Ultraviolet (UVA & UVB) Two wavelength “types” of UV reach the earth’s surface – UVA (320-400nm) and UVB (290-320nm). Most of the UVB and all UVC are filtered by stratospheric ozone. UVA was initially thought to be noncarcinogenic, but is now thought to be a potent co-carcinogen with UVB. Recently, high dose UVA (as found in tanning beds) has...
متن کاملBasal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice.
Loss-of-function mutations in Patched (Ptch1) are implicated in constitutive activation of the Sonic hedgehog pathway in human basal cell carcinomas (BCCs), and inherited Ptch1 mutations underlie basal cell nevus syndrome in which a typical feature is multiple BCC occurring with greater incidence in portals of radiotherapy. Mice in which one copy of Ptch1 is inactivated show increased susceptib...
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Basal cell carcinoma (BCC) is currently the most common cutaneous cancer found in humans. Although it generally shows a relatively benign course (BCCl), some cases show aggressive behavior (BCC2). Until recently, traditional histologic diagnostic criteria have failed to discriminate unequivocally between BCC 1 and BCC2. In this study we selected 50 cases of BCC and categorized them into tw...
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Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering the fact that COX2 expression has not been evaluated in radiation-in...
متن کاملBasal cell carcinoma of the lower extremities
Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional study was conducted on 650 BCC patients, who were referred to the dermatology tumor ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.02.140